Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Despite the advent of sophisticated and efficient new biologics to treat inflammation in
asthma, the disease persists. Even following treatment, many patients still experience the …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

Single cell RNA-seq has revolutionized transcriptomics by providing cell type resolution for
differential gene expression and expression quantitative trait loci (eQTL) analyses. However …

Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the
underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS …

Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
Genotypes in the core region defined by the first genome-wide association study correlate …