Pathologists have recognized arterial calcification for over a century. Recent years have
witnessed a strong resurgence of interest in atherosclerotic plaque calcification because it …

Core binding factors are heterodimeric transcription factors containing a DNA binding
Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBFβ subunit. All four …

Homozygous loss of function of Runx1 (Runt-related transcription factor 1 gene) during
murine development results in an embryonic lethal phenotype characterized by a complete …

Megakaryocytic and erythroid lineages derive from a common bipotential progenitor and
share many transcription factors, most prominently factors of the GATA zinc-finger family …

Runx2 (runt-related transcription factor 2, also known as Cbfa1, Osf2 and AML3) is essential
for bone development in mice, and mutations in RUNX2 are found in 65–80% of individuals …

The transcription factor Runx1 marks all functional hematopoietic stem cells (HSCs) in the
embryo and is required for their generation. Mutations in Runx1 are found in approximately …

The aim of this study was to identify deregulated transcription factors (TFs) in colorectal
cancer (CRC) and to evaluate their relation with the recurrence of stage II CRC and overall …

The Runx1/core binding factor-β (CBFβ) transcriptional complex is required for the
establishment of hematopoiesis during development. Despite its critical role during …

BACKGROUND AND OBJECTIVES: Mutations of KIT receptor tyrosine kinase are involved
in the constitutive activation and development of human hematologic malignancies. Gain-of …

Acute myeloid leukaemia (AML) has been proposed to arise from the collaboration between
two classes of mutation, a class I, or proliferative, mutation and a class II, or blocking …