Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Considering that hypoxia is closely associated with tumor proliferation, invasion, metastasis,
and drug resistance, it is of great significance to overcome hypoxia in tumor treatment …

Sonodynamic therapy (SDT), which involves a combination of low-intensity ultrasound (US)
and a chemical sonosensitizer, has emerged as a promising minimally invasive and …

Prodrugs are chemically modified drug molecules that are inactive before administration.
After administration, they are converted in situ to parent drugs and induce the mechanism of …

The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal
to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell …

Stilbenes are some of the important phenolic compounds originating from plant families like
Vitaceae, Leguminaceae, Gnetaceae, and Dipterocarpaceae. Structurally, they have a C6 …

Implantable devices on the tumor tissue as a local treatment are able to work in situ, which
minimizes systemic toxicities and adverse effects. Here, we demonstrated an implantable …

Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has
emerged as one of the most effective methods for cancer therapy. Nevertheless, single …