L-selectin: a major regulator of leukocyte adhesion, migration and signaling
A Ivetic, HL Hoskins Green, SJ Hart - Frontiers in immunology, 2019 - frontiersin.org
L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …
Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy
Objective: To examine the relationships between blood CD4 natural regulatory T (T reg)
cells, plasma HIV RNA level, CD4 T-cell count and immune activation in untreated HIV …
cells, plasma HIV RNA level, CD4 T-cell count and immune activation in untreated HIV …
Infrequent HIV infection of circulating monocytes during antiretroviral therapy
M Massanella, W Bakeman, P Sithinamsuwan… - Journal of …, 2019 - Am Soc Microbiol
Whereas human immunodeficiency virus (HIV) persists in tissue macrophages during
antiretroviral therapy (ART), the role of circulating monocytes as HIV reservoirs remains …
antiretroviral therapy (ART), the role of circulating monocytes as HIV reservoirs remains …
Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy
P Price, N Mathiot, R Krueger, S Stone… - Journal of Clinical …, 2001 - Elsevier
Background: Some immune defects caused by HIV infection resolve following treatment with
highly active antiretroviral therapy (HAART), but residual immune dysfunction may cause …
highly active antiretroviral therapy (HAART), but residual immune dysfunction may cause …
[HTML][HTML] Efficient magnetic bead-based separation of HIV-1-infected cells using an improved reporter virus system reveals that p53 up-regulation occurs exclusively in …
HIV-1 infection in cell lines is very efficient, since the target population is clonal and highly
dividing. However, infection of primary cells such as CD4 T lymphocytes and monocyte …
dividing. However, infection of primary cells such as CD4 T lymphocytes and monocyte …
Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma
D Widney, G Gundapp, JW Said, M van der Meijden… - Clinical …, 1999 - Elsevier
CD27 is a member of the tumor necrosis factor receptor superfamily that is expressed
primarily on T cells, as well as on subsets of B cells and NK cells. CD70, which is expressed …
primarily on T cells, as well as on subsets of B cells and NK cells. CD70, which is expressed …
HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes
L Vassena, E Giuliani, H Koppensteiner… - Journal of …, 2015 - Am Soc Microbiol
Leukocyte recirculation between blood and lymphoid tissues is required for the generation
and maintenance of immune responses against pathogens and is crucially controlled by the …
and maintenance of immune responses against pathogens and is crucially controlled by the …
Suppression of Foxo1 activity and down-modulation of CD62L (L-selectin) in HIV-1 infected resting CD4 T cells
HIV-1 hijacks and disrupts many processes in the cells it infects in order to suppress antiviral
immunity and to facilitate its replication. Resting CD4 T cells are important early targets of …
immunity and to facilitate its replication. Resting CD4 T cells are important early targets of …
A novel high-throughput microwell outgrowth assay for HIV-infected cells
AD Fenton, N Archin, AM Turner, S Joseph… - Journal of …, 2024 - Am Soc Microbiol
Although antiretroviral therapy (ART) is effective at suppressing HIV replication, a viral
reservoir persists that can reseed infection if ART is interrupted. Curing HIV will require …
reservoir persists that can reseed infection if ART is interrupted. Curing HIV will require …
Productive infection of double-negative T cells with HIV in vivo
G Marodon, D Warren, MC Filomio… - Proceedings of the …, 1999 - National Acad Sciences
HIV induces CD4 down-regulation from the surface of infected cells by several independent
mechanisms, suggesting an important biological role for this phenomenon. In vitro CD4 …
mechanisms, suggesting an important biological role for this phenomenon. In vitro CD4 …