Organ failure due to systemic injury in acute pancreatitis

PK Garg, VP Singh - Gastroenterology, 2019 - Elsevier
Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …

Obesity and pancreatitis

B Khatua, B El-Kurdi, VP Singh - Current opinion in …, 2017 - journals.lww.com
We discuss how obesity may contribute to increasing acute pancreatitis incidence, the role
of lipolytic unsaturated fatty acid release in worsening acute pancreatitis, and potential …

Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis …

P Noel, K Patel, C Durgampudi, RN Trivedi… - Gut, 2016 - gut.bmj.com
Background and aims Peripancreatic fat necrosis occurs frequently in necrotising
pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is …

[HTML][HTML] Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and …

K Patel, RN Trivedi, C Durgampudi, P Noel… - The American journal of …, 2015 - Elsevier
Visceral fat necrosis has been associated with severe acute pancreatitis (SAP) for over 100
years; however, its pathogenesis and role in SAP outcomes are poorly understood. Based …

Role of pancreatic fat in the outcomes of pancreatitis

C Acharya, S Navina, VP Singh - Pancreatology, 2014 - Elsevier
The role of obesity in relation to various disease processes is being increasingly studied,
with reports over the last several years increasingly mentioning its association with worse …

The clinical relevance of obesity in acute pancreatitis: targeted systematic reviews

R Premkumar, ARJ Phillips, MS Petrov, JA Windsor - Pancreatology, 2015 - Elsevier
Background With the rising prevalence of obesity, its impact on the severity and outcome of
acute pancreatitis remains an important consideration when managing obese patients with …

Association of visceral adipose tissue on the incidence and severity of acute pancreatitis: a systematic review

LL Kuan, AR Dennison, G Garcea - Pancreatology, 2020 - Elsevier
Background With the rising prevalence of obesity, there is a plethora of literature discussing
the relationship between obesity and acute pancreatitis (AP). Evidence has shown a …

Impact of body fat and muscle distribution on severity of acute pancreatitis

SB Yoon, MH Choi, IS Lee, CH Lim, JS Kim, YK Cho… - Pancreatology, 2017 - Elsevier
Abstract Background/Objectives Obesity is a well-established risk factor for severe acute
pancreatitis (AP); however, the impact of visceral obesity or sarcopenic obesity on severity of …

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

S Pérez, S Rius‐Pérez, I Finamor… - The Journal of …, 2019 - Wiley Online Library
Obesity is associated with local and systemic complications in acute pancreatitis. PPARγ
coactivator 1α (PGC‐1α) is a transcriptional coactivator and master regulator of …

[HTML][HTML] Quantification of visceral adipose tissue by computed tomography and magnetic resonance imaging: reproducibility and accuracy

LC Pescatori, E Savarino, G Mauri, E Silvestri… - Radiologia …, 2019 - SciELO Brasil
Objective: To evaluate the feasibility of quantifying visceral adipose tissue (VAT) on
computed tomography (CT) and magnetic resonance imaging (MRI) scans, using freeware …