Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

Are you feeling emotionally fragile, moody, unpredictable, even ungenerous to those around
you? Here, we review how and why these phenomena can occur as a result of insufficient …

Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened
latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram …

JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Aims To systematically review the literature on the efficacy and tolerability of the major
chronotherapeutic treatments of bipolar disorders (BD)—bright light therapy (LT), dark …

Aims Given the lasting impact of chronic paradoxical sleep deprivation (PSD) on behavior
and organism metabolic alternations, along with the role of the microbiome in …

Sleep-wake disorders are highly prevalent disorders, which can lead to negative effects on
cognitive, emotional and interpersonal functioning, and can cause maladaptive metabolic …