In Situ Synthesis and Assembly of Functional Materials and Devices in Living Systems
Conspectus Integrating functional materials and devices with living systems enables novel
methods for recording, manipulating, or augmenting organisms not accessible by traditional …
methods for recording, manipulating, or augmenting organisms not accessible by traditional …
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs
Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors
that enable mammalian cells to detect environmental signals and respond by activating user …
that enable mammalian cells to detect environmental signals and respond by activating user …
Graphene-integrated mesh electronics with converged multifunctionality for tracking multimodal excitation-contraction dynamics in cardiac microtissues
Cardiac microtissues provide a promising platform for disease modeling and developmental
studies, which require the close monitoring of the multimodal excitation-contraction …
studies, which require the close monitoring of the multimodal excitation-contraction …
Multimodal charting of molecular and functional cell states via in situ electro-sequencing
Paired map** of single-cell gene expression and electrophysiology is essential to
understand gene-to-function relationships in electrogenic tissues. Here, we developed in …
understand gene-to-function relationships in electrogenic tissues. Here, we developed in …
The emerging role of heart‐on‐a‐chip systems in delineating mechanisms of SARS‐CoV‐2‐induced cardiac dysfunction
Abstract Coronavirus disease 2019 (COVID‐19) has been a major global health concern
since its emergence in 2019, with over 680 million confirmed cases as of April 2023. While …
since its emergence in 2019, with over 680 million confirmed cases as of April 2023. While …
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control cellular phenotypes in multi-cellular constructs
Synthetic Notch (synNotch) receptors are modular synthetic components that are genetically
engineered into mammalian cells to detect signals presented by neighboring cells and …
engineered into mammalian cells to detect signals presented by neighboring cells and …
Biohybrid printing approaches for cardiac pathophysiological studies
Bioengineered hearts, which include single cardiomyocytes, engineered heart tissue, and
chamber-like models, generate various biosignals, such as contractility …
chamber-like models, generate various biosignals, such as contractility …
High-Throughput Cardiomyocytes Biosensing: From Single-Parameter Detection to Integrated Mechano-Electrophysiological Platforms
L Zhang, J Han, F Zhang, X Pan, J Ding… - ACS Applied …, 2025 - ACS Publications
Develo** the in vitro cardiac sensing platform is promising to study cardiac physiology,
disease mechanisms, drug development, and personalized medicine. Changes in the …
disease mechanisms, drug development, and personalized medicine. Changes in the …
Advancing Cardiac Organoid Engineering Through Application of Biophysical Forces
Cardiac organoids represent an important bioengineering opportunity in the development of
models to study human heart pathophysiology. By incorporating multiple cardiac cell types …
models to study human heart pathophysiology. By incorporating multiple cardiac cell types …
Sex-Based Mechanisms of Cardiac Development and Function: Applications for Induced-Pluripotent Stem Cell Derived-Cardiomyocytes
Males and females exhibit intrinsic differences in the structure and function of the heart,
while the prevalence and severity of cardiovascular disease vary in the two sexes. However …
while the prevalence and severity of cardiovascular disease vary in the two sexes. However …