Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology

I Bervoets, D Charlier - FEMS microbiology reviews, 2019 - academic.oup.com
Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Contextualizing context for synthetic biology–identifying causes of failure of synthetic biological systems

S Cardinale, AP Arkin - Biotechnology journal, 2012 - Wiley Online Library
Despite the efforts that bioengineers have exerted in designing and constructing biological
processes that function according to a predetermined set of rules, their operation remains …

Synthetic genetic circuits as a means of reprogramming plant roots

JAN Brophy, KJ Magallon, L Duan, V Zhong… - Science, 2022 - science.org
The shape of a plant's root system influences its ability to reach essential nutrients in the soil
and to acquire water during drought. Progress in engineering plant roots to optimize water …

[BUCH][B] The emergence of life: from chemical origins to synthetic biology

PL Luisi - 2016 - books.google.com
Addressing the emergence of life from a systems biology perspective, this new edition has
undergone extensive revision, reflecting changes in scientific understanding and evolution …

Distributed biological computation with multicellular engineered networks

S Regot, J Macia, N Conde, K Furukawa, J Kjellén… - Nature, 2011 - nature.com
Ongoing efforts within synthetic and systems biology have been directed towards the
building of artificial computational devices using engineered biological units as basic …

Partitioning of a 2-bit hash function across 66 communicating cells

JP Padmakumar, JJ Sun, W Cho, Y Zhou… - Nature Chemical …, 2024 - nature.com
Powerful distributed computing can be achieved by communicating cells that individually
perform simple operations. Here, we report design software to divide a large genetic circuit …

Towards a rational approach to promoter engineering: understanding the complexity of transcription initiation in prokaryotes

C Deal, L De Wannemaeker… - FEMS Microbiology …, 2024 - academic.oup.com
Promoter sequences are important genetic control elements. Through their interaction with
RNA polymerase they determine transcription strength and specificity, thereby regulating the …

Next-generation synthetic gene networks

TK Lu, AS Khalil, JJ Collins - Nature biotechnology, 2009 - nature.com
Synthetic biology is focused on the rational construction of biological systems based on
engineering principles. During the field's first decade of development, significant progress …

Synthetic in vitro transcriptional oscillators

J Kim, E Winfree - Molecular systems biology, 2011 - embopress.org
The construction of synthetic biochemical circuits from simple components illuminates how
complex behaviors can arise in chemistry and builds a foundation for future biological …

Quantitative characterization of genetic parts and circuits for plant synthetic biology

KA Schaumberg, MS Antunes, TK Kassaw, W Xu… - Nature …, 2016 - nature.com
Plant synthetic biology promises immense technological benefits, including the potential
development of a sustainable bio-based economy through the predictive design of synthetic …