Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer's disease detection

V Vimbi, N Shaffi, M Mahmud - Brain Informatics, 2024 - Springer
Explainable artificial intelligence (XAI) has gained much interest in recent years for its ability
to explain the complex decision-making process of machine learning (ML) and deep …

Explainable artificial intelligence in Alzheimer's disease classification: A systematic review

V Viswan, N Shaffi, M Mahmud, K Subramanian… - Cognitive …, 2024 - Springer
The unprecedented growth of computational capabilities in recent years has allowed
Artificial Intelligence (AI) models to be developed for medical applications with remarkable …

[HTML][HTML] Treatment of Alzheimer's disease: beyond symptomatic therapies

FR Buccellato, M D'Anca, GM Tartaglia… - International Journal of …, 2023 - mdpi.com
In an ever-increasing aged world, Alzheimer's disease (AD) represents the first cause of
dementia and one of the first chronic diseases in elderly people. With 55 million people …

BACE1: More than just a β‐secretase

HA Taylor, L Przemylska, EM Clavane… - Obesity …, 2022 - Wiley Online Library
Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline

C Boccalini, F Ribaldi, I Hristovska… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Tau and neurodegeneration strongly correlate with cognitive impairment,
as compared to amyloid. However, their contribution in explaining cognition and predicting …

Lower GLUT1 and unchanged MCT1 in Alzheimer's disease cerebrovasculature

M Leclerc, C Tremblay, P Bourassa… - Journal of Cerebral …, 2024 - journals.sagepub.com
The brain is a highly demanding organ, utilizing mainly glucose but also ketone bodies as
sources of energy. Glucose transporter-1 (GLUT1) and monocarboxylates transporter-1 …

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease

MT Duong, SR Das, X Lyu, L **e, H Richardson… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better
correlated to neurodegeneration (N). However, T and N have complex regional relationships …

Advit: Vision transformer on multi-modality pet images for alzheimer disease diagnosis

X **ng, G Liang, Y Zhang, S Khanal… - 2022 IEEE 19th …, 2022 - ieeexplore.ieee.org
We present a new model trained on multi-modalities of Positron Emission Tomography
images (PET-AV45 and PET-FDG) for Alzheimer's Disease (AD) diagnosis. Unlike the …

Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems

L Capatina, E Todirascu-Ciornea, EM Napoli… - Antioxidants, 2020 - mdpi.com
Thymus vulgaris L. is an aromatic herb used for medicinal purposes such as antimicrobial,
spasmolytic, antioxidant, anti-inflammatory, antinociceptive, antitumor, and may have …

[HTML][HTML] Systematic comparison of 3D Deep learning and classical machine learning explanations for Alzheimer's Disease detection

L Bloch, CM Friedrich… - Computers in Biology …, 2024 - Elsevier
Black-box deep learning (DL) models trained for the early detection of Alzheimer's Disease
(AD) often lack systematic model interpretation. This work computes the activated brain …