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Chronic lymphocytic leukaemia: from genetics to treatment
Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
Targeting mitosis in cancer: emerging strategies
The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …
The molecular pathogenesis of chronic lymphocytic leukaemia
G Fabbri, R Dalla-Favera - Nature Reviews Cancer, 2016 - nature.com
Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells
M Hudecek, MT Lupo-Stanghellini… - Clinical cancer …, 2013 - aacrjournals.org
Purpose: The adoptive transfer of T cells modified to express a chimeric antigen receptor
(CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a …
(CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a …
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
Y Herishanu, P Pérez-Galán, D Liu… - Blood, The Journal …, 2011 - ashpublications.org
Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes,
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
S Ponader, SS Chen, JJ Buggy… - Blood, The Journal …, 2012 - ashpublications.org
B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell
malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by …
malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by …
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or …
Background Most patients with chronic lymphocytic leukaemia or small lymphocytic
lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the …
lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the …
The multidimensional role of the Wnt/β‐catenin signaling pathway in human malignancies
Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …
Chronic lymphocytic leukemia
N Chiorazzi, KR Rai, M Ferrarini - New England Journal of …, 2005 - Mass Medical Soc
Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone
remarkable changes during the past decade. This review addresses the latest ideas …
remarkable changes during the past decade. This review addresses the latest ideas …