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Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
Clinical trials and progress in metastatic colon cancer
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide but mortality
associated with this disease has declined in recent decades due to improved screening …
associated with this disease has declined in recent decades due to improved screening …
[HTML][HTML] c-MET overexpression in colorectal cancer: a poor prognostic factor for survival
SJ Lee, J Lee, SH Park, JO Park, HY Lim… - Clinical colorectal …, 2018 - Elsevier
Introduction Increased mesenchymal-epithelial transition factor gene (c-MET) expression in
several human malignancies is related to increased tumor progression and is a new …
several human malignancies is related to increased tumor progression and is a new …
Vimentin immunoexpression is associated with higher tumor grade, metastasis, and shorter survival in colorectal cancer
J Al-Maghrabi - … journal of clinical and experimental pathology, 2020 - pmc.ncbi.nlm.nih.gov
Background/Aim: The association between vimentin immunoexpression and poor prognosis
has been described in many human cancers. The objective of this study was to evaluate the …
has been described in many human cancers. The objective of this study was to evaluate the …
RNAscope in situ hybridization confirms mRNA integrity in formalin-fixed, paraffin-embedded cancer tissue samples
V Bingham, L McIlreavey, C Greene, E O'Doherty… - …, 2017 - pmc.ncbi.nlm.nih.gov
Immunohistochemistry remains the overwhelming technique of choice for test biomarker
evaluation in both clinical or research settings when using formalin-fixed, paraffin embedded …
evaluation in both clinical or research settings when using formalin-fixed, paraffin embedded …
Prognostic value of HER2 status in bladder transitional cell carcinoma revealed by both IHC and BDISH techniques
Background Her2/neu is an oncogene that plays an important role in the pathogenesis of
many cancer types. In bladder carcinoma (BC), the clinical significance of Her2/neu status …
many cancer types. In bladder carcinoma (BC), the clinical significance of Her2/neu status …
C‐Met as a potential target for the treatment of gastrointestinal cancer: Current status and future perspectives
Aberrant activation of the HGF/c‐Met signalling pathways is shown to be related with cell
proliferation, progression, metastasis, and worse prognosis in several tumor types, including …
proliferation, progression, metastasis, and worse prognosis in several tumor types, including …
Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
J Yao, X Li, L Yan, S He, J Zheng… - … of Biochemical and …, 2019 - Wiley Online Library
The system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in
tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of …
tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of …
miR-146a targets c-met and abolishes colorectal cancer liver metastasis
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types
of cancer, is disease progression via liver metastases. At this stage, very few treatment …
of cancer, is disease progression via liver metastases. At this stage, very few treatment …
c-Met-Targeting 19F MRI Nanoparticles with Ultralong Tumor Retention for Precisely Detecting Small or Ill-Defined Colorectal Liver Metastases
Purpose Precisely detecting colorectal liver metastases (CLMs), the leading cause of
colorectal cancer-associated mortality, is extremely important. 1H MRI with high soft tissue …
colorectal cancer-associated mortality, is extremely important. 1H MRI with high soft tissue …