Iron homeostasis and organismal aging
Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …
red blood cell function and many essential proteins and enzymes required for numerous …
MicroRNAs as modulators of longevity and the aging process
HE Kinser, Z Pincus - Human genetics, 2020 - Springer
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress
translation or induce mRNA degradation of target transcripts through sequence-specific …
translation or induce mRNA degradation of target transcripts through sequence-specific …
miR‐29a‐3p in Exosomes from Heme Oxygenase‐1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia‐Reperfusion Injury in Rats …
X Li, L Wu, X Tian, W Zheng, M Yuan… - Oxidative Medicine …, 2022 - Wiley Online Library
Hepatic ischemia‐reperfusion injury (IRI) is an inevitable result of liver surgery. Steatotic
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …
livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis is considered to …
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick… - Molecular systems …, 2020 - embopress.org
A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
Collagen type XI alpha 1 (COL11A1): a novel biomarker and a key player in cancer
S Nallanthighal, JP Heiserman, DJ Cheon - Cancers, 2021 - mdpi.com
Simple Summary Collagen type XI alpha 1 (COL11A1) is a part of type XI collagen, which is
important for bone development. Interestingly, COL11A1 levels are frequently upregulated in …
important for bone development. Interestingly, COL11A1 levels are frequently upregulated in …
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke
Stem cell-based treatments have been suggested as promising candidates for stroke.
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …
Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for …
Exosomes from miR-19b-3p-modified ADSCs inhibit ferroptosis in intracerebral hemorrhage mice
X Yi, X Tang - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Objectives: Effective treatments for intracerebral hemorrhage (ICH) are limited until now.
Ferroptosis, a novel form of iron-dependent cell death, is implicated in neurodegeneration …
Ferroptosis, a novel form of iron-dependent cell death, is implicated in neurodegeneration …
MicroRNAs in the Onset of Schizophrenia
KT Thomas, SS Zakharenko - Cells, 2021 - mdpi.com
Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
MicroRNAs, long non-coding RNAs, and circular RNAs in the redox control of cell senescence
Cell senescence is critical in diverse aspects of organism life. It is involved in tissue
development and homeostasis, as well as in tumor suppression. Consequently, it is tightly …
development and homeostasis, as well as in tumor suppression. Consequently, it is tightly …