Accumulating evidence suggests that the response of bacteria to antibiotics is significantly
affected by the presence of other interacting microbes. These interactions are not typically …

The environment is increasingly being recognized for the role it might play in the global
spread of clinically relevant antibiotic resistance. Environmental regulators monitor and …

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The
past few decades have witnessed rapid progress in our understanding of the multiple factors …

Surface-associated microbial communities, called biofilms, are present in all environments.
Although biofilms play an important positive role in a variety of ecosystems, they also have …

The widespread use of antibiotics results in the generation of antibiotic concentration
gradients in humans, livestock and the environment. Thus, bacteria are frequently exposed …

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …

Highlights•Quaternary ammonium compounds (QACs) are disinfectants used in many
applications.•Bacteria exposed to sub-inhibitory QAC concentrations develop …

The presence of an abnormal amount of single-stranded DNA in the bacterial cell constitutes
a genotoxic alarm signal that induces the SOS response, a broad regulatory network found …

Antibiotics are vital in the treatment of bacterial infectious diseases but when released into
the environment they may impact non-target organisms that perform vital ecosystem services …

New drug deployment strategies are imperative to address the problem of drug resistance,
which is limiting the management of infectious diseases and cancers. We evolved resistance …