For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects motor and
cognition functions. The etiology of Parkinson's disease remains largely unknown, but …

Background Parkinson's disease (PD) exhibits a high prevalence of dementia as disease
severity and duration progress. Focused ultrasound (FUS) has been applied for transient …

The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …

As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …

Background: We have hypothesized that Parkinson's disease (PD) comprises two subtypes.
Brain-first, where pathogenic α-synuclein initially forms unilaterally in one hemisphere …

The striatal dopaminergic deficit in Parkinson's disease exhibits a typical pattern, extending
from the caudal and dorsal putamen at onset to its more rostral region as the disease …

Objective: This study aimed to prove the concept of a new optical video-based system to
measure Parkinson's disease (PD) remotely using an accessible standard webcam …

Walking detection in the daily life of patients with Parkinson's disease (PD) is of great
significance for tracking the progress of the disease. This study aims to implement an …

Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been
related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson's …