Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor
dysfunction. Aging is the greatest risk factor for develo** PD. Recent molecular genetic …

Introduction Variants in the leucine-rich repeat kinase 2 gene (LRRK2) are risk factors for
Parkinson's disease (PD), but their prevalence varies geographically, reflecting the locations …

Knowledge on the genetic basis of Parkinson's disease has grown tremendously since the
discovery of the first monogenic form, caused by a mutation in α-synuclein, and with the …

To investigate the prevalence and genotype-phenotype correlations of parkin RBR E3
ubiquitin protein ligase (PRKN) variants in Parkinson's disease (PD), we first included 2,527 …

Missense variants in leucine-rich repeat kinase 2 (LRRK2) lead to familial and sporadic
Parkinson's disease (PD). The pathological features of PD patients with LRRK2 variants …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease,
characterized by the specific loss of dopaminergic neurons in the midbrain. The …

Leucine-rich repeat kinase 2 (LRRK2) is a large protein kinase that physiologically
phosphorylates and regulates the function of several Rab proteins. LRRK2 is genetically …

Parkinson's disease (PD) is a heterogenous neurodegenerative disorder. Genetic factors
play a significant role, especially in early onset and familial cases. Mutations are usually …

Introduction: There has been a bias in the existing literature on Parkinson's disease (PD)
genetics as most studies involved patients of European ancestry, mostly in Europe and …

The increasing availability of molecular genetic testing has changed the landscape of both
genetic research and clinical practice. Not only is the pace of discovery of novel disease …