The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular
smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) …

RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps
ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have …

Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

Adequate reprogramming of cellular metabolism in response to stresses or suboptimal
growth conditions involves a myriad of coordinated changes that serve to promote cell …

Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor
neurons. Ribonuclease inactivating point mutations are found in a subset of patients with …

Adaptation to changes in extracellular tonicity is essential for cell survival. However, severe
or chronic hyperosmotic stress induces apoptosis, which involves cytochrome c (Cyt c) …

Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response
program in mammalian cells. Here we show that ANG inhibits protein synthesis and …

As a member of the vertebrate-specific secreted ribonucleases, angiogenin (ANG) was first
isolated and identified solely by its ability to induce new blood vessel formation, and now, it …