Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Pancreatic cancer is a disease caused by the accumulation of genetic alterations in specific
genes. Elucidation of the human genome sequence, in conjunction with technical advances …

Purpose: Evaluate the efficacy of an SN-38-anti-Trop-2 antibody–drug conjugate (ADC)
against several human solid tumor types, and to assess its tolerability in mice and monkeys …

The clinical and pathological features of carcinomas of the pancreas with DNA replication
errors (RER+) have not been characterized. Eighty-two xenografted carcinomas of the …

Cell death of gastrointestinal epithelial cells occurs by a process referred to as apoptosis. In
this review, we succinctly define apoptosis and summarize the role of apoptosis in the …

The DNA-damage response (DDR) pathways consist of interconnected components that
respond to DNA damage to allow repair and promote cell survival. The DNA repair pathways …

Cancer of the pancreas is a genetic disease. Sporadic cancers of the pancreas are
frequently associated with the activation of an oncogene, K-ras, and the inactivation of …

Simple Summary Epigenetic alterations contribute to the distinct biology of pancreatic ductal
adenocarcinoma (PDAC) and thus allow a better understanding of molecular mechanisms …

purpose. To investigate the relationship between development of the perifoveal blood
vessels and formation of the foveal depression. methods. Retinal sections and flatmounts …

Pancreatic cancer (PC) is thought to develop through a series of duct lesions termed
pancreatic intraepithelial neoplasia (PanIN). Characterization of the molecular pathology of …