During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

▪ Abstract Protein complexes consisting of s tructural m aintenance of c hromosomes (SMC)
and kleisin subunits are crucial for the faithful segregation of chromosomes during cell …

Background The growing trend for women to postpone childbearing has resulted in a
dramatic increase in the incidence of trisomic pregnancies. Maternal age-related …

Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

Meiosis is the type of cell division that gives rise to eggs and sperm. Errors in the execution
of this process can result in the generation of aneuploid gametes, which are associated with …

Events controlling cell division are governed by the degradation of different regulatory
proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a …

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase
that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and …

Mammalian oocytes are particularly error prone in segregating their chromosomes during
their two meiotic divisions. This results in the creation of an embryo that has inherited the …