Abstract Anthraquinones (9, 10‐dioxoanthracenes) constitute an important class of natural
and synthetic compounds with a wide range of applications. Besides their utilization as …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of
intercellular communication, signaling via nucleotides. The signaling cascades involved in …

Highlights•Antiplatelet agents play a key role in the therapy of acute coronary syndromes
(ACS).•P2Y 12 antagonists inhibit processes important for both thrombosis and …

The extracellular ATP/adenosine axis in the tumor microenvironment (TME) has emerged as
an important immune-regulatory pathway. Nucleoside triphosphate diphosphohydrolase-1 …

Ecto-nucleotidases are nucleotide metabolizing enzymes that are divided into four different
families; nucleoside triphosphate diphosphohydrolases (NTPDases), ecto-5′-nucleotidase …

Objectives Beta vulgaris, commonly known as beetroot, is a vegetable that contains red
pigment and rich in betalains, phenolic acids, and flavonoids. This study was designed to …

Studies implicating an important role for apyrase (NTPDase) enzymes in plant growth and
development began appearing in the literature more than three decades ago. After early …

Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …