Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …

Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …

Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies
indicate a substantial heritable component, but the underlying mechanisms remain unclear …

ABSTRACT DNA molecules are highly compacted in the eukaryotic nucleus where distal
regulatory elements reach their targets through three-dimensional chromosomal …

Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …

Myeloma is characterized by extensive inter-patient genomic heterogeneity due to multiple
different initiating events. A recent multi-region sequencing study demonstrated spatial …

Simple Summary Artificial intelligence (AI) is a field that combines computer science with
robust datasets to solve problems. AI in medicine uses machine learning and deep learning …

Lymphoid neoplasms represent a heterogeneous group of disease entities and subtypes
with markedly different molecular and clinical features. Beyond genetic alterations, lymphoid …

Multiple myeloma (MM) is a malignant plasma cell disorder accounting for around 1.8% of
all neoplastic diseases. Nowadays, clinicians have a broad arsenal of drugs at their disposal …

Multiple myeloma is an incurable plasma B-cell malignancy with 5-year survival rates
approximately 10-30% lower than other hematologic cancers. Treatment options include …