Hypericin and its anticancer effects: From mechanism of action to potential therapeutic application

N Choudhary, TE Collignon, D Tewari, A Bishayee - Phytomedicine, 2022 - Elsevier
Background Emerging studies indicate that hypericin has diverse pharmacological actions
and exhibits potential for treatment of various types of cancer. Purpose The current review …

Hypericin as a promising natural bioactive naphthodianthrone: A review of its pharmacology, pharmacokinetics, toxicity, and safety

Z Peng, J Lu, K Liu, L **e, Y Wang, C Cai… - Phytotherapy …, 2023 - Wiley Online Library
Hypericin can be derived from St. John's wort, which is widely spread around the world. As a
natural product, it has been put into clinical practice such as wound healing and depression …

Structural Characterization and Anticancer Activity of a New Anthraquinone from Senna velutina (Fabaceae)

DTH Castro, DF Leite, D da Silva Baldivia… - Pharmaceuticals, 2023 - mdpi.com
In this study, a novel compound was isolated, identified, and its chemical structure was
determined from the extract of the roots of Senna velutina. In addition, we sought to evaluate …

Anti-cancer impact of Hypericin in B-CPAP cells: Extrinsic caspase dependent apoptosis induction and metastasis obstruction

M Piryaei, B Mehrparvar, A Mohammadian… - European Journal of …, 2021 - Elsevier
Thyroid cancer is the most common type of endocrine-related cancer. According to the
literature, its incidence is not very high, but its rate increasing especially in developed …

Transcriptome analysis evinces anti-neoplastic mechanisms of hypericin: A study on U87 glioblastoma cell line

S Ghiasvand, MA Javidi, A Mohammadian, SA Mousavi… - Life Sciences, 2021 - Elsevier
Abstract Aims Hypericin (HYP) from Hypericum perforatum has cytotoxic effects on a variety
of malignant cell types, but the pattern of gene expression mediating the effect is largely …

Fluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer—A Pilot Study

C Yurttas, P Horvath, I Fischer, S Wagner… - Journal of Clinical …, 2024 - mdpi.com
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out
peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been …

Hypericin-mediated regulation of miR21 and miR34a and their target genes in MCF7 breast cancer cells

R Norouzi, S Ghotbzadeh-Kermani… - Revista Brasileira de …, 2023 - Springer
Hypericin is a polyphenolic compound derived from Hypericum perforatum L.,
Hypericaceae, that exhibits cytotoxic activity in various cancer cell types. The molecular …

Inhibition by Hypericin of Tongue Squamous Carcinoma Cell Proliferation and Treatment of Resistance in Dental Pulp Stem Cells

F Tondro, S Shahbazi, F Shahriari, AM Ansari… - Revista Brasileira de …, 2024 - Springer
Tongue cancer is a malignancy affecting the head and neck region that has exhibited an
increased incidence in recent decades, primarily attributed to alterations in lifestyle patterns …

[PDF][PDF] Antitumor activity and phenolic profile of Melissa officinalis extract against human gastric adenocarcinoma cells.

AA Hashim, D Altememy, MH Mahdi… - Pakistan Journal of …, 2024 - researchgate.net
Gastric cancer remains a global health concern, driving the exploration of natural products
with anticancer potential. This study investigated the antiproliferative activity and chemical …

Study on antioxidant and cytotoxic properties of Ephedra major Host. hydroalcoholic extract on AGS gastric carcinoma cell line.

F Moraghebi, SA Yamchelo, SM Maddah - 2023 - cabidigitallibrary.org
Gastric cancer is a malignant tumor that is one of the most common types of cancer in the
world and Iran. Plants are rich sources of a variety of antioxidant compounds which can be …