Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Late-stage diversification of natural products is an efficient way to generate natural product
derivatives for drug discovery and chemical biology. Benefiting from the development of site …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

Reactions that directly install nitrogen into C–H bonds of complex molecules are significant
because of their potential to change the chemical and biological properties of a given …

Many enzymes oxidize unactivated aliphatic C–H bonds selectively to form alcohols;
however, biological systems do not possess enzymes that catalyse the analogous …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

We report a manganese-catalyzed aliphatic C–H azidation reaction that can efficiently
convert secondary, tertiary, and benzylic C–H bonds to the corresponding azides. The …

N–N linkages are found in many natural compounds and endow fascinating structural and
functional properties. In comparison to the myriad methods for the construction of C–N …

The application of small molecules as catalysts for the diversification of natural product
scaffolds is reviewed. Specifically, principles that relate to the selectivity challenges intrinsic …