In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …

Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology
of major depressive disorder (MDD). However, previous findings have been inconsistent …

Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Objective: Cannabis use is increasing among midlife and older adults. This study tested the
hypotheses that long-term cannabis use is associated with cognitive deficits and smaller …

Background Alzheimer's disease (AD) is the leading cause of dementia. Currently, there are
no effective disease-modifying treatments for AD. Mendelian randomisation (MR) has been …

The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and
its subfields differ in architecture and function. Genome-wide association studies on …

Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …

Structural hippocampal abnormalities are common in many neurological and psychiatric
disorders, and variation in hippocampal measures is related to cognitive performance and …