The eukaryotic 5′ untranslated region (UTR) is critical for ribosome recruitment to the
messenger RNA (mRNA) and start codon choice and plays a major role in the control of …

Translational control plays an essential role in the regulation of gene expression. It is
especially important in defining the proteome, maintaining homeostasis, and controlling cell …

Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …

Heat causes protein misfolding and aggregation and, in eukaryotic cells, triggers
aggregation of proteins and RNA into stress granules. We have carried out extensive …

African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, presenting the
biggest global threat to animal farming in recorded history. Despite the importance of ASFV …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Viruses exploit the translation machinery of an infected cell to synthesize their proteins.
Therefore, viral mRNAs have to compete for ribosomes and translation factors with cellular …

Background Eukaryotic ribosomes are widely presumed to scan mRNA for the AUG codon to
initiate translation in a strictly 5′–3′ movement (ie, strictly unidirectional scanning model) …

Ribosomes have the capacity to selectively control translation through changes in their
composition that enable recognition of specific RNA elements. However, beyond differential …

African swine fever virus (ASFV) represents a severe threat to global agriculture with the
world's domestic pig population reduced by a quarter following recent outbreaks in Europe …