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The expanding world of tRNA modifications and their disease relevance
Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …
Naturally occurring modified ribonucleosides
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …
m5U-SVM: identification of RNA 5-methyluridine modification sites based on multi-view features of physicochemical features and distributed representation
Abstract Background RNA 5-methyluridine (m5U) modifications are obtained by methylation
at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is …
at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is …
[HTML][HTML] Epitranscriptome: review of top 25 most-studied RNA modifications
VA Arzumanian, GV Dolgalev, IY Kurbatov… - International Journal of …, 2022 - mdpi.com
The alphabet of building blocks for RNA molecules is much larger than the standard four
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …
Attention-based multi-label neural networks for integrated prediction and interpretation of twelve widely occurring RNA modifications
Recent studies suggest that epi-transcriptome regulation via post-transcriptional RNA
modifications is vital for all RNA types. Precise identification of RNA modification sites is …
modifications is vital for all RNA types. Precise identification of RNA modification sites is …
RNA nucleotide methylation: 2021 update
Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
Sequence-and structure-specific cytosine-5 mRNA methylation by NSUN6
The highly abundant N6-methyladenosine (m6A) RNA modification affects most aspects of
mRNA function, yet the precise function of the rarer 5-methylcytidine (m5C) remains largely …
mRNA function, yet the precise function of the rarer 5-methylcytidine (m5C) remains largely …
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …
Although composed of different chemistries, more than 40 types of human tRNA …
Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation
Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a
major gap in our understanding of the RNA chemistry present in biological systems. Here we …
major gap in our understanding of the RNA chemistry present in biological systems. Here we …
Why U matters: detection and functions of pseudouridine modifications in mRNAs
The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are
present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human …
present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human …