Leishmania donovani is the causative organism of the neglected human disease known as
visceral leishmaniasis which is often fatal, if left untreated. The cysteine biosynthesis …

Several retrospective epidemiological reports have indicated an inverse correlation between
smoking and development of Parkinson's disease (PD). This has mostly been attributed to …

Epidemiological studies report a beneficial relationship between drinking coffee and the risk
of develo** Parkinson's disease (PD). This is likely due to caffeine, a constituent of coffee …

Mutations in adenine biosynthesis pathway genes ADE1 and ADE2 have been
conventionally used to score for prion [PSI+] in yeast. If ade1‐14 mutant allele is present …

Protein aggregation and oxidative stress are two pathological hallmarks of a number of
protein misfolding diseases, including Huntington's disease (HD). Whether protein …

Despite the significant amount of experimental data available on trehalose, the molecular
mechanism responsible for its intracellular stabilising properties has not emerged yet. The …

Huntington's disease (HD) is associated with the misfolding and aggregation of mutant
huntingtin harboring an elongated polyglutamine stretch at its N terminus. A distinguishing …

Conflicting reports exist in the literature regarding the role of wild-type huntingtin in
determining the toxicity of the aggregated, mutant huntingtin in Huntington's disease (HD) …

Proteolytic cleavage of huntingtin gives rise to N‐terminal fragments. While the role of
truncated mutant huntingtin is described in Huntington's disease (HD) pathogenesis, the …

Chronic stress and prolonged activation of defence pathways have deleterious
consequences for the cell. Dietary restriction is believed to be beneficial as it induces the …