Importance Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory
disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and …

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Coordinated cell interactions within the esophagus maintain homeostasis, and disruption
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …

Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4+ T helper 2
(Th2) cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth …

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Eosinophilic esophagitis is an increasingly common diagnosis among children evaluated for
feeding problems and among adults with dysphagia and food impaction. This review …

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …

The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …