Melanoma is the leading cause of global skin cancer-related death and currently ranks as
the third most commonly diagnosed cancer in Australia. Melanoma patients with in-transit …

Deep learning (DL) has become one of the major approaches in computational
dermatopathology, evidenced by a significant increase in this topic in the current literature …

Background The liver is a known site of resistance to immunotherapy and the presence of
liver metastases is associated with shorter progression-free and overall survival (OS) in …

Background Molecular subty** is expected to enable precise treatment. However, reliable
subty** strategies for clinical application remains defective and controversial. Given the …

Background Tumor microenvironment (TME) characteristics are potential biomarkers of
response to immune checkpoint inhibitors in metastatic melanoma. This study developed a …

Immune checkpoint inhibitors (ICIs) have demonstrated impressive antitumor activity in
patients with advanced and early stage melanoma, thus improving long-term survival …

Cutaneous melanoma is a highly aggressive form of skin cancer. The development of
immune checkpoint inhibitors (ICIs) has revolutionized the management of advanced …

Abstract Purpose: Cytokines IL2 and IL12 exhibit potent anticancer activity but suffer a
narrow therapeutic window due to off-tumor immune cell activation. Engineering cytokines …

Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous
nature and high metastatic potential. The incidence of melanoma is continuously increasing …

Purpose: The spatial variability and clinical relevance of the tumor immune
microenvironment (TIME) are still poorly understood for hepatocellular carcinoma (HCC). In …