3D electron diffraction: the nanocrystallography revolution

M Gemmi, E Mugnaioli, TE Gorelik, U Kolb… - ACS central …, 2019 - ACS Publications
Crystallography of nanocrystalline materials has witnessed a true revolution in the past 10
years, thanks to the introduction of protocols for 3D acquisition and analysis of electron …

Electron diffraction of 3D molecular crystals

A Saha, SS Nia, JA Rodríguez - Chemical Reviews, 2022 - ACS Publications
Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data

PB Klar, Y Krysiak, H Xu, G Steciuk, J Cho, X Zou… - Nature Chemistry, 2023 - nature.com
Continuous-rotation 3D electron diffraction methods are increasingly popular for the
structure analysis of very small organic molecular crystals and crystalline inorganic …

Measurement of charges and chemical bonding in a cryo-EM structure

S Maki-Yonekura, K Kawakami, K Takaba… - Communications …, 2023 - nature.com
Hydrogen bonding, bond polarity, and charges in protein molecules play critical roles in the
stabilization of protein structures, as well as affecting their functions such as enzymatic …

Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography

K Takaba, S Maki-Yonekura, I Inoue, K Tono… - Nature …, 2023 - nature.com
Abstract Structure analysis of small crystals is important in areas ranging from synthetic
organic chemistry to pharmaceutical and material sciences, as many compounds do not …

Locating Hydrogen Positions for COF‐300 by Cryo‐3D Electron Diffraction

W Sun, P Chen, M Zhang, JX Ma, J Sun - Angewandte Chemie, 2023 - Wiley Online Library
Covalent organic frameworks (COFs) have wide‐ranging applications, and their host–guest
interactions play an essential role in the achievement of COF functions. To investigate these …

MicroED in natural product and small molecule research

E Danelius, S Halaby, WA van der Donk… - Natural product …, 2021 - pubs.rsc.org
Covering: 2013 to 2020 The electron cryo-microscopy (cryo-EM) method Microcrystal
Electron Diffraction (MicroED) allows the collection of high-resolution structural data from …

Doses for X‐ray and electron diffraction: New features in RADDOSE‐3D including intensity decay models

JL Dickerson, PTN McCubbin… - Protein …, 2024 - Wiley Online Library
New features in the dose estimation program RADDOSE‐3D are summarised. They include
the facility to enter a diffraction intensity decay model which modifies the “Diffraction …

Visualizing the entire range of noncovalent interactions in nanocrystalline hybrid materials using 3D electron diffraction

Y Luo, MTB Clabbers, J Qiao, Z Yuan… - Journal of the …, 2022 - ACS Publications
Noncovalent interactions are essential in the formation and properties of a diverse range of
hybrid materials. However, reliably identifying the noncovalent interactions in …

Characterization of reactive organometallic species via MicroED

CG Jones, M Asay, LJ Kim, JF Kleinsasser… - ACS central …, 2019 - ACS Publications
Here we apply microcrystal electron diffraction (MicroED) to the structural determination of
transition-metal complexes. We find that the simultaneous use of 300 keV electrons, very low …