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Emerging evidence for adapting radiotherapy to immunotherapy
Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …
infrequently associated with durable objective responses when used as a standalone …
A review of proton therapy–Current status and future directions
The original rationale for proton therapy was its highly conformal depth‐dose distributions
compared to photons, which allow greater sparing of normal tissues and escalation of tumor …
compared to photons, which allow greater sparing of normal tissues and escalation of tumor …
Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
Current state of immunotherapy for glioblastoma
Glioma is the most common primary cancer of the central nervous system, and around 50%
of patients present with the most aggressive form of the disease, glioblastoma. Conventional …
of patients present with the most aggressive form of the disease, glioblastoma. Conventional …
Radiobiology of the FLASH effect
Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …
than in current clinical radiotherapy (RT) have been shown to manifest differential …
Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma
Severe and prolonged lymphopenia frequently occurs in patients with glioblastoma after
standard chemoradiotherapy and has been associated with worse survival, but its …
standard chemoradiotherapy and has been associated with worse survival, but its …
A review on lymphocyte radiosensitivity and its impact on radiotherapy
It is well known that radiation therapy causes lymphopenia in patients and that this is
correlated with a negative outcome. The mechanism is not well understood because …
correlated with a negative outcome. The mechanism is not well understood because …
Charged-particle therapy in cancer: clinical uses and future perspectives
Radiotherapy with high-energy charged particles has become an attractive therapeutic
option for patients with several tumour types because this approach better spares healthy …
option for patients with several tumour types because this approach better spares healthy …
Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma
X Wang, G Guo, H Guan, Y Yu, J Lu, J Yu - Journal of Experimental & …, 2019 - Springer
Abstract PD-1/PD-L1 checkpoint blockades have achieved significant progress in several
kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line …
kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line …
CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges
In patients with certain hematologic malignancies, the use of autologous T cells genetically
modified to express chimeric antigen receptors (CARs) has led to unprecedented clinical …
modified to express chimeric antigen receptors (CARs) has led to unprecedented clinical …