Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and
memory. Accumulating evidence suggests that glia participates in sculpting the neuronal …

Lipids are small molecule immunomodulators that play critical roles in maintaining cellular
health and function. Microglia, the resident immune cells of the central nervous system …

Whether soluble TREM2 has a functional role in the central nervous system has been
unclear. In this issue of Immunity, Zhong et al. show that soluble TREM2 inhibits aberrant …

Alzheimer's Disease (AD) is a chronic neurodegenerative disorder that clinically manifests
as the most common form of dementia. Due to their surveillance functions and …