Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

CRISPR gene editing holds great promise to modify DNA sequences in somatic cells to treat
disease. However, standard computational and biochemical methods to predict off-target …

Abstract G-quadruplex (G4) structural motifs have been linked to transcription 1, 2,
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA.
Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is …

Noncoding RNAs (ncRNAs) play crucial regulatory roles in a variety of biological circuits. To
document regulatory interactions between ncRNAs and biomolecules, we previously …

Several mechanisms of action have been proposed for DNA methyltransferase and histone
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches …

Coding variants represent many of the strongest associations between genotype and
phenotype; however, they exhibit inter-individual differences in effect, termed 'variable …

Advances in high-throughput DNA sequencing have revolutionized the discovery of variants
in the human genome; however, interpreting the phenotypic effects of those variants is still a …