Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Interferon-γ (IFN-γ) is an important mediator of immunity and inflammation that utilizes the
JAK-STAT signaling pathway to activate the STAT1 transcription factor. Many functions of …

Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark
of many chronic degenerative diseases. By using a model of acute peritoneal inflammation …

Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular
pathogenic B cells derived from newly activated naive cells. Although these cells express …

Although chemokines are sufficient for chemotaxis of various cells, increasing evidence
exists for their fine-tuning by selective proteolytic processing. Using a model of immune cell …

Pro-inflammatory cytokines promote autoimmune inflammation and tissue damage, while
anti-inflammatory cytokines help resolve inflammation and facilitate tissue repair. Over the …

Metformin, a well known antidiabetic agent that improves peripheral insulin sensitivity, also
elicits anti-inflammatory actions, but its mechanism is unclear. Here, we investigated the …

Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein
entry, retention, and oxidative modification cause endothelial damage, triggering innate and …

Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-
γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However …