RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …

Engineering T lymphocytes is an emerging approach in a variety of biomedical applications.
However, delivering large biologics to primary T lymphocytes directly in vivo is technically …

Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically
advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of …

In situ vaccination is a promising strategy for cancer immunotherapy owing to its
convenience and the ability to induce numerous tumor antigens. However, the advancement …