Conditioning of the immune system by the microbiome

DB Graham, RJ Xavier - Trends in Immunology, 2023 - cell.com
The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

dbCAN3: automated carbohydrate-active enzyme and substrate annotation

J Zheng, Q Ge, Y Yan, X Zhang, L Huang… - Nucleic Acids …, 2023 - academic.oup.com
Carbohydrate active enzymes (CAZymes) are made by various organisms for complex
carbohydrate metabolism. Genome mining of CAZymes has become a routine data analysis …

From microbiome composition to functional engineering, one step at a time

SD Burz, S Causevic, A Dal Co… - Microbiology and …, 2023 - Am Soc Microbiol
Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly

Y Shao, C Garcia-Mauriño, S Clare, NJR Dawson… - Nature …, 2024 - nature.com
Human microbiota assembly commences at birth, seeded by both maternal and
environmental microorganisms. Ecological theory postulates that primary colonizers dictate …

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

HMOs Exert Marked Bifidogenic Effects on Children's Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition

D Bajic, F Wiens, E Wintergerst, S Deyaert, A Baudot… - Nutrients, 2023 - mdpi.com
Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring
a health benefit. There is a growing awareness that interpersonal and age-dependent …

[HTML][HTML] Niche availability and competitive loss by facilitation control proliferation of bacterial strains intended for soil microbiome interventions

S Čaušević, M Dubey, M Morales, G Salazar… - Nature …, 2024 - nature.com
Microbiome engineering–the targeted manipulation of microbial communities–is considered
a promising strategy to restore ecosystems, but experimental support and mechanistic …

Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year

M Selma-Royo, L Dubois, S Manara, F Armanini… - Cell host & …, 2024 - cell.com
The composition and maturation of the early-life microbiota are modulated by a number of
perinatal factors, whose interplay in relation to microbial vertical transmission remains …

Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition

T Portlock, T Shama, SH Kakon, B Hartjen… - Nature …, 2025 - nature.com
Malnutrition affects over 30 million children annually and has profound immediate and
enduring repercussions. Survivors often suffer lasting neurocognitive consequences that …

A metagenomic catalog of the early-life human gut virome

S Zeng, A Almeida, S Li, J Ying, H Wang, Y Qu… - Nature …, 2024 - nature.com
Early-life human gut microbiome is a pivotal driver of gut homeostasis and infant health.
However, the viral component (known as “virome”) remains mostly unexplored. Here, we …