Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Cardiogenic growth factors play important roles in heart development. Placental growth
factor (PLGF) has previously been reported to have angiogenic effects; however, its potential …

Occlusion of coronary artery and subsequent damage or death of myocardium can lead to
myocardial infarction (MI) and even heart failure—one of the leading causes of deaths world …

Induced pluripotent stem cells (iPSCs) have become a prevalent topic after their discovery,
advertised as an ethical alternative to embryonic stem cells (ESCs). Due to their ability to …

Brugada syndrome (BrS) is an inherited and rare cardiac arrhythmogenic disease
associated with an increased risk of ventricular fibrillation and sudden cardiac death …

Background: During cardiogenesis, cardiac cells receive various stimuli, such as
biomechanical and chemical cues, from the surrounding microenvironment, and these …

BACKGROUND: Discovering determinants of cardiomyocyte maturity is critical for deeply
understanding the maintenance of differentiated states and potentially reawakening …