Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair
loss ranging from patches on the scalp to complete hair loss involving the entire body …

Small molecule JAK inhibitors have emerged as a major therapeutic advancement in
treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that …

The innate immune regulator STING is a critical sensor of self-and pathogen-derived DNA.
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …

Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes
and results in patches of depigmentation that are visible as white spots. Recent research …

Background Alopecia areata (AA) is an autoimmune form of hair loss with limited treatments.
Objective To evaluate the efficacy and safety of the Janus kinase inhibitors ritlecitinib and …

Computational approaches for understanding compound-protein interactions (CPIs) can
greatly facilitate drug development. Recently, a number of deep-learning-based methods …

Abstract The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and
dendritic cells in response to microbial stimulation, has emerged as a critical promoter of …

Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

Background & Aims The efficacy and safety of ritlecitinib (oral JAK3/TEC family kinase
inhibitor) and brepocitinib (oral TYK2/JAK1 inhibitor) as induction therapy were assessed in …