Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a
pathological disorganized wound healing process with chronic inflammation. The TGF …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT 1 R) blockers, current …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Abstract Angiotensin-converting enzyme (ACE)—a zinc-dependent dicarboxypeptidase with
two catalytic domains—plays a major part in blood pressure regulation by converting …

Background Angiotensin converting enzyme (ACE) was isolated as a 'hypertensinconverting
enzyme'. There have been considerable advances in understanding the metabolic role of …

The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

One of the biggest challenges in the management of obesity is the prevention of weight
regain after successful weight loss. Weight regain after weight loss has large interindividual …

Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the
renin–angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides …

There is increasing interest in the origins of chronic obstructive pulmonary disease (COPD),
as it is envisaged that preventive efforts and treatment can modify its clinical course. The …