Entrapment neuropathies such as carpal tunnel syndrome, radiculopathies, or radicular pain
are the most common peripheral neuropathies and also the most common cause for …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Human brain imaging has revealed that acute pain results from activation of a network of
brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In …

Peripheral nerve injuries (PNIs) may result in cellular and molecular changes in supraspinal
structures possibly involved in neuropathic pain (NPP) maintenance. Activated glial cells in …

Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …

Background Calcitonin gene-related peptide (CGRP) receptor antagonism is an approach to
migraine therapy. The locus of action of antimigraine treatment is not resolved. The objective …

When neuropathic pain is maintained long term, it can also lead to the development of
emotional disorders that are even more intense than pain perception and difficult to treat …

Background Chronic neuropathic pain is a neuro-immune disorder, characterised by
allodynia, hyperalgesia and spontaneous pain, as well as debilitating affective-motivational …

Neuropathic pain, a chronic pain due to neuronal lesion, remains unaltered even after the
injury-induced spinal afferent discharges have declined, suggesting an involvement of …

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic
condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still …