Asthma treatment goals currently focus on symptom and exacerbation control rather than
remission. Remission is not identical to cure, but is a step closer. This review considers the …

Asthma is a complex respiratory disorder characterized by marked heterogeneity in
individual patient disease triggers and response to therapy. Several asthma phenotypes …

Background Exacerbations of asthma cause a substantial global illness burden. Adults with
uncontrolled persistent asthma despite maintenance treatment require additional therapy …

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic
airway diseases that have a high personal and social impact. They likely represent a …

The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …

Background Elevated sputum eosinophil counts predict asthma exacerbations and
responsiveness to inhaled corticosteroids but are impractical to measure in primary care. We …

Background Persistent eosinophilic airway inflammation in asthma increases the risk of
exacerbations. In a phase 2b dose-ranging study, we aimed to assess the efficacy and …

Background Monitoring sputum eosinophils in asthma predicts exacerbations and improves
management of asthma. Thus far, blood eosinophils and FENO show contradictory results in …

Background Airway neutrophilic inflammation is a pathological feature in some patients with
severe asthma. Stimulation of the chemokine receptor CXCR2 mediates neutrophil …

Among patients with asthma, heterogeneity exists regarding the pattern of airway
inflammation and response to treatment, prompting the necessity of recognizing specific …