Engineered organoids for biomedical applications
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …
rapidly emerging as powerful tools for biomedical applications. With their potential for …
[HTML][HTML] The molecular basis of mammary gland development and epithelial differentiation
PF Slepicka, AVH Somasundara… - Seminars in cell & …, 2021 - Elsevier
Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …
organ systems has been increasing rapidly in recent years. With the advent of new and …
Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis
Organoid culture has been extensively exploited for normal tissue reconstruction and
disease modeling. However, it is still challenging to establish organoids that mimic in vivo …
disease modeling. However, it is still challenging to establish organoids that mimic in vivo …
[HTML][HTML] Current status of breast organoid models
SC Mohan, TY Lee, AE Giuliano, X Cui - Frontiers in Bioengineering …, 2021 - frontiersin.org
Breast cancer (BC) is the most frequently diagnosed malignancy among women globally.
Although mouse models have been critical in advancing the knowledge of BC tumorigenesis …
Although mouse models have been critical in advancing the knowledge of BC tumorigenesis …
Culture Models to investigate mechanisms of milk production and blood-milk barrier in mammary epithelial cells: a review and a protocol
K Kobayashi - Journal of Mammary Gland Biology and Neoplasia, 2023 - Springer
Mammary epithelial cells (MECs) are the only cell type that produces milk during lactation.
MECs also form less-permeable tight junctions (TJs) to prevent the leakage of milk and …
MECs also form less-permeable tight junctions (TJs) to prevent the leakage of milk and …
[HTML][HTML] Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology
In recent years, the development of 3D organoids has opened new avenues of investigation
into development, physiology, and regenerative medicine. Organoid formation and the …
into development, physiology, and regenerative medicine. Organoid formation and the …
[HTML][HTML] Role of succinylation modification in thyroid cancer and breast cancer
R Mu, Z Ma, C Lu, H Wang, X Cheng… - American Journal of …, 2021 - ncbi.nlm.nih.gov
The incidence of thyroid cancer and breast cancer is increasing year by year, and the
specific pathogenesis is unclear. Posttranslational modifications constitute an important …
specific pathogenesis is unclear. Posttranslational modifications constitute an important …
Organoid models for mammary gland dynamics and breast cancer
The mammary gland is a highly dynamic tissue that undergoes repeated cycles of growth
and involution during pregnancy and menstruation. It is also the site from which breast …
and involution during pregnancy and menstruation. It is also the site from which breast …
Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods
SM Lewis, MK Callaway… - … Biology and Medicine, 2022 - journals.sagepub.com
While mouse models and two-dimensional (2D) cell culture systems have dominated as
research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a …
research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a …
Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration
Signaling pathways play an important role in cell fate determination in stem cells and
regulate a plethora of developmental programs, the dysregulation of which can lead to …
regulate a plethora of developmental programs, the dysregulation of which can lead to …