Blue-light receptors for optogenetics

A Losi, KH Gardner, A Möglich - Chemical reviews, 2018 - ACS Publications
Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

H Serrage, V Heiskanen, WM Palin… - Photochemical & …, 2019 - pubs.rsc.org
Photobiomodulation (PBM) describes the application of light at wavelengths ranging from
400–1100 nm to promote tissue healing, reduce inflammation and promote analgesia …

Molecular engineering of the TGF-β signaling pathway

Z Zi - Journal of molecular biology, 2019 - Elsevier
Transforming growth factor beta (TGF-β) is an important growth factor that plays essential
roles in regulating tissue development and homeostasis. Dysfunction of TGF-β signaling is a …

Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling

JY Wu, K Yeager, DN Tavakol, M Morsink, B Wang… - Cell reports, 2023 - cell.com
In tissue development and homeostasis, transforming growth factor (TGF)-β signaling is
finely coordinated by latent forms and matrix sequestration. Optogenetics can offer precise …

Optical activation of TrkA signaling

L Duan, JM Hope, S Guo, Q Ong, A François… - ACS synthetic …, 2018 - ACS Publications
Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in
neuronal development, function, survival, and growth. The pathway is implicated in …

Optogenetics sheds new light on tissue engineering and regenerative medicine

W Hu, Q Li, B Li, K Ma, C Zhang, X Fu - Biomaterials, 2020 - Elsevier
Optogenetics has demonstrated great potential in the fields of tissue engineering and
regenerative medicine, from basic research to clinical applications. Spatiotemporal …

Immunoreceptor engineering and synthetic cytokine signaling for therapeutics

J Scheller, E Engelowski, JM Moll, DM Floss - Trends in immunology, 2019 - cell.com
Cytokines control immune-related events and are critically involved in a plethora of
physiological and pathophysiological processes including autoimmunity and cancer …

Optogenetic control of the BMP signaling pathway

PA Humphreys, S Woods, CA Smith, N Bates… - ACS Synthetic …, 2020 - ACS Publications
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β
(TGFβ) superfamily and have crucial roles during development; including mesodermal …

Optogenetic control of Nodal signaling patterns

HM McNamara, BZ Jia, A Guyer, VJ Parot, C Dobbs… - …, 2024 - pmc.ncbi.nlm.nih.gov
A crucial step in early embryogenesis is the establishment of spatial patterns of signaling
activity. Tools to perturb morphogen signals with high resolution in space and time can help …

[HTML][HTML] Optogenetic approaches for the spatiotemporal control of signal transduction pathways

MM Kramer, L Lataster, W Weber… - International Journal of …, 2021 - mdpi.com
Biological signals are sensed by their respective receptors and are transduced and
processed by a sophisticated intracellular signaling network leading to a signal-specific …