Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Objectives: Antimicrobial use is growing, driven mainly by rising demands in develo**
countries. Knowing how antimicrobials are prescribed is important. Consequently, we …

Flucytosine is an antifungal agent first licensed in the 1970's. However, its clinical value has
long been overlooked and its availability across the globe is limited. This review highlights …

Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in
patients with HIV infection. The antifungal pharmacological treatment is limited to …

Cryptococcal meningoencephalitis was first described over a century ago. This fungal
infection is preventable and treatable yet continues to be associated with excessive …

Background Four decades into the HIV epidemic, CNS infection remains a leading cause of
preventable HIV-related deaths in routine care. The Driving Reduced AIDS-associated …

Candida infections are varied and, depending on the immune status of the patient, a life-
threatening form may develop. C. albicans is the most prevalent species isolated, however …

Cryptococcosis causes a high burden of disease worldwide. This systematic review
summarizes the literature on Cryptococcus neoformans and C. gattii infections to inform the …

The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client
proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal …