Colorectal cancer is the third most common and the second deadliest cancer worldwide. To
date, colorectal cancer becomes one of the most important challenges of the health system …

Ovarian cancer represents one of the most aggressive female tumors worldwide. Over the
decades, the therapeutic options for the treatment of ovarian cancer have been improved …

Background It is estimated that more than 20% of ovarian cancer cases are associated with
a genetic predisposition that is only partially explained by germline mutations in the BRCA1 …

While cancer cells gain aggressiveness by mutations, abundant mutations release
neoantigens, attracting anti-cancer immune cells. We hypothesized that in breast cancer …

Next-generation sequencing (NGS) has been increasingly popular in genomics studies over
the last decade, as new sequencing technology has been created and improved. Recently …

Background Hereditary breast cancer (BC), ovarian cancer (OC), and pancreatic cancer
(PC) are the major BRCA-associated tumours. However, some BRCA1/2-wild-type (wt) …

Hereditary cancer syndromes (HCS) account for 5~ 10% of all cancer diagnosis. Lynch
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …

Simple Summary The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating
DNA double-strand break repair and activating several downstream proteins. These proteins …

Juvenile polyposis syndrome (JPS) is an inherited autosomal dominant condition that
predisposes to the development of juvenile polyps throughout the gastrointestinal (GI) tract …

Gene mutations may affect the fate of many tumors including prostate cancer (PCa);
therefore, the research of specific mutations associated with tumor outcomes might help the …