Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Post-stroke cognitive impairment: epidemiology, risk factors, and management

YY Huang, SD Chen, XY Leng, K Kuo… - Journal of …, 2022 - content.iospress.com
Stroke, characterized as a neurological deficit of cerebrovascular cause, is very common in
older adults. Increasing evidence suggests stroke contributes to the risk and severity of …

Age-related immune alterations and cerebrovascular inflammation

CE Finger, I Moreno-Gonzalez, A Gutierrez… - Molecular …, 2022 - nature.com
Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice

C Robba, G Bonatti, D Battaglini, PRM Rocco, P Pelosi - Critical Care, 2019 - Springer
Most patients with ischaemic stroke are managed on the ward or in specialty stroke units, but
a significant number requires higher-acuity care and, consequently, admission to the …

New insights into the roles of microglial regulation in brain plasticity-dependent stroke recovery

F Yu, T Huang, Y Ran, D Li, L Ye, G Tian… - Frontiers in Cellular …, 2021 - frontiersin.org
Stroke remains the leading cause of long-term disability worldwide with significant long-term
sequelae. However, there is no highly effective treatment to enhance post-stroke recovery …

[HTML][HTML] CD11bhigh B cells increase after stroke and regulate microglia

JM Korf, P Honarpisheh, EC Mohan… - The Journal of …, 2022 - journals.aai.org
Recent studies have highlighted the deleterious contributions of B cells to post-stroke
recovery and cognitive decline. Different B cell subsets have been proposed on the basis of …

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade

K Winek, S Lobentanzer, B Nadorp… - Proceedings of the …, 2020 - National Acad Sciences
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance
between inflammatory responses and immune suppression, tip** the scale between brain …