1, 3, 4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities

A Vaidya, D Pathak, K Shah - Chemical biology & drug design, 2021 - Wiley Online Library
Abstract The 1, 3, 4‐oxadiazole nucleus is a biologically imperative scaffold possesses
numerous biological activities. The broad and potent activity of 1, 3, 4‐oxadiazole and their …

Therapeutic potential of oxadiazole or furadiazole containing compounds

A Siwach, PK Verma - BMC chemistry, 2020 - Springer
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important
class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two …

Novel hybrids of benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment

R Bhutani, DP Pathak, G Kapoor, A Husain… - Bioorganic chemistry, 2019 - Elsevier
A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …

Synthesis of some new 1, 3, 4-oxadiazole derivatives and evaluation of their anticancer activity

L Yurttaş, AE Evren, A Kubilay, MO Aksoy… - ACS …, 2023 - ACS Publications
In this work, some new 2-[(5-((2-acetamidophenoxy) methyl)-1, 3, 4-oxadiazol-2-yl) thio]
acetamide derivatives (4a-4l) were synthesized and studied for their anticancer activity …

Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity …

R Bhutani, DP Pathak, G Kapoor, A Husain, R Kant… - Bioorganic …, 2018 - Elsevier
A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …

[PDF][PDF] Synthesis and Biological Evaluationof Novel 1, 3, 4-Oxadiazole Derivatives as Antimicrobial Agents

PB Parekar, SD Sonwane, VN Dhakane… - Journal of …, 2023 - jcdronline.org
The major drawback of current treatment of infectious diseases are challenging due to
resistance to antimicrobial agents and their side effects. In order to overcome this situation, it …

1, 3, 4-Oxadiazole containing compounds as therapeutic targets for cancer therapy

MJ Ahsan - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …

Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1, 3, 4-oxadiazole-2-thione derivatives as potential anticancer agents

S Bajaj, PP Roy, J Singh - Computational Biology and Chemistry, 2018 - Elsevier
Abstract A series of novel 1, 3, 4-oxadiazole-2-thione derivatives were designed,
synthesized and evaluated for in vitro anticancer activity against breast cancer (MCF-7) cell …

Novel 1, 3, 4-oxadiazole targets STAT3 signaling to induce antitumor effect in lung cancer

VH Malojirao, SS Girimanchanaika, MK Shanmugam… - Biomedicines, 2020 - mdpi.com
Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the
global context. STAT3 is an oncogenic transcription factor that is persistently activated in …

Identification of phenylcarbamoylazinane-1, 3, 4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies

B Bashir, W Shahid, M Ashraf, M Saleem, S Muzaffar… - Bioorganic …, 2021 - Elsevier
In search for new anti-inflammatory agents that inhibit the enzymes of arachidonic acid
pathway as the drug targets, the present article describes the screening of 1, 3, 4-oxadiazole …