Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …

Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt)(orexin)
precursor or Hcrt receptor genes. In contrast to these animal models, most human …

NEW case descriptions offer additional practice in working your way through real-life
scenarios to reach an accurate diagnosis and an effective treatment plan for neurologic …

Abstract [This book presents] explanations of motivation, using an eclectic framework that
balances biological, behavioral, and cognitive theories. Not only are these theories …

The neuropeptide orexin (also known as hypocretin) is hypothesized to play a critical role in
the regulation of sleep–wake behavior. Lack of orexin produces narcolepsy, which is …

Recent advances indicate that a robust physiologic system acts to maintain relative
constancy of weight in mammals. A key component of this system is leptin. Leptin is an …

It has recently been reported that Parkinson's disease (PD) is preceded and accompanied
by daytime sleep attacks, nocturnal insomnia, REM sleep behaviour disorder, hallucinations …

The present article provides a brief overview of various aspects on neuropeptides,
emphasizing their multitude and their wide distribution in both the peripheral and central …

Hypocretin has been identified as a regulator of metabolic and endocrine systems. Several
brain regions involved in the central regulation of autonomic and endocrine processes or …

Orexins-A and-B are neuropeptides derived from a single precursor prepro-orexin. The
mature peptides are mainly expressed in the lateral hypothalamic and perifornical areas …