Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …
antigenic changes in the spike protein are neutralized less efficiently by serum antibodies …
[HTML][HTML] Targeting innate immune pathways for cancer immunotherapy
LL Cao, JC Kagan - Immunity, 2023 - cell.com
The innate immune system is critical for inducing durable and protective T cell responses to
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70
Messenger RNA (mRNA) vaccines were pivotal in reducing severe acute respiratory
syndrome 2 (SARS-CoV-2) infection burden, yet they have not demonstrated robust …
syndrome 2 (SARS-CoV-2) infection burden, yet they have not demonstrated robust …
Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19
ABSTRACT SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in the
death of millions worldwide since the beginning of the pandemic in December 2019. While …
death of millions worldwide since the beginning of the pandemic in December 2019. While …
Circular RNA vaccine induces potent T cell responses
Circular RNAs (circRNAs) are a class of RNAs commonly found across eukaryotes and
viruses, characterized by their resistance to exonuclease-mediated degradation. Their …
viruses, characterized by their resistance to exonuclease-mediated degradation. Their …
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Abstract Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
against heterologous pathogens. However, the underlying mechanisms remain mysterious …
The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …