Tuberculosis vaccines and prevention of infection

TR Hawn, TA Day, TJ Scriba, M Hatherill… - Microbiology and …, 2014‏ - Am Soc Microbiol
Tuberculosis (TB) is a leading cause of death worldwide despite the availability of effective
chemotherapy for over 60 years. Although Mycobacterium bovis bacillus Calmette-Guérin …

Efficacy and safety of BCG vaccine for control of tuberculosis in domestic livestock and wildlife

BM Buddle, HM Vordermeier, MA Chambers… - Frontiers in veterinary …, 2018‏ - frontiersin.org
Bovine tuberculosis (TB) continues to be an intractable problem in many countries,
particularly where “test and slaughter” policies cannot be implemented or where wildlife …

Bovine tuberculosis vaccine research: historical perspectives and recent advances

WR Waters, MV Palmer, BM Buddle, HM Vordermeier - Vaccine, 2012‏ - Elsevier
The emergence of wildlife reservoirs of Mycobacterium bovis infection in cattle as well as
increased inter-regional trade with associated spread of M. bovis has led to renewed interest …

Next-generation vaccines based on Bacille Calmette–Guérin

NE Nieuwenhuizen, SHE Kaufmann - Frontiers in immunology, 2018‏ - frontiersin.org
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb),
remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette …

Bovine tuberculosis in cattle: vaccines, DIVA tests, and host biomarker discovery

HM Vordermeier, GJ Jones, BM Buddle… - Annual review of …, 2016‏ - annualreviews.org
Bovine tuberculosis remains a major economic and animal welfare concern worldwide.
Cattle vaccination is being considered as part of control strategies. This approach, used …

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination

A Fromsa, K Willgert, S Srinivasan, G Mekonnen… - Science, 2024‏ - science.org
Bacillus Calmette-Guérin (BCG) is a routinely used vaccine for protecting children against
Mycobacterium tuberculosis that comprises attenuated Mycobacterium bovis. BCG can also …

A meta-analysis of the effect of Bacillus Calmette-Guérin vaccination against bovine tuberculosis: is perfect the enemy of good?

S Srinivasan, AJK Conlan, LA Easterling… - Frontiers in Veterinary …, 2021‏ - frontiersin.org
More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide,
highlighting an urgent need for bTB control strategies in low-and middle-income countries …

Field Evaluation of the Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin against Bovine Tuberculosis in Neonatal Calves in Ethiopia

G Ameni, M Vordermeier, A Aseffa… - Clinical and Vaccine …, 2010‏ - Am Soc Microbiol
In develo** countries, the conventional test and slaughter strategy for the control of bovine
tuberculosis is prohibitively expensive, and alternative control methods such as vaccination …

Vaccination against tuberculosis in badgers and cattle: an overview of the challenges, developments and current research priorities in Great Britain

MA Chambers, SP Carter, GJ Wilson, G Jones… - Veterinary …, 2014‏ - Wiley Online Library
Bovine tuberculosis (TB) is a significant threat to the cattle industry in England and Wales. It
is widely acknowledged that a combination of measures targeting both cattle and wildlife will …

Overview of vaccination trials for control of tuberculosis in cattle, wildlife and humans

BM Buddle, NA Parlane, DN Wedlock… - Transboundary and …, 2013‏ - Wiley Online Library
Vaccination is a key strategy for control of tuberculosis (TB), and considerable progress has
been made in the past 5 years to develop improved vaccines for humans and animals …