Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …
Although the previous edition of this classification was published just 5 years earlier, in …
Brain borders at the central stage of neuroimmunology
The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …
the immune system. However, recent studies have highlighted the borders of the central …
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
DNA-framework-based multidimensional molecular classifiers for cancer diagnosis
A molecular classification of diseases that accurately reflects clinical behaviour lays the
foundation of precision medicine. The development of in silico classifiers coupled with …
foundation of precision medicine. The development of in silico classifiers coupled with …
The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know—a minireview
Abstract Background The World Health Organization (WHO) Classification of Tumours, also
known as WHO Blue Books, represents an international standardised tool in the diagnostic …
known as WHO Blue Books, represents an international standardised tool in the diagnostic …
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
Abstract Treatment of the tumor and dural margin with surgery and sometimes radiation are
cornerstones of therapy for meningioma. Molecular classifications have provided insights …
cornerstones of therapy for meningioma. Molecular classifications have provided insights …
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population
Y Qu, J Feng, X Wu, L Bai, W Xu, L Zhu, Y Liu… - Nature …, 2022 - nature.com
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …
Radiogenomic-based multiomic analysis reveals imaging intratumor heterogeneity phenotypes and therapeutic targets
Intratumor heterogeneity (ITH) profoundly affects therapeutic responses and clinical
outcomes. However, the widespread methods for assessing ITH based on genomic …
outcomes. However, the widespread methods for assessing ITH based on genomic …
Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas
Recurrence of meningiomas is unpredictable by current invasive methods based on
surgically removed specimens. Identification of patients likely to recur using noninvasive …
surgically removed specimens. Identification of patients likely to recur using noninvasive …
Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …
histopathological grading will behave malignantly. To better diagnose these tumors, several …